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Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
- Lee, Jongkook;
- Han, Sun-Young;
- Jung, Heejung;
- Yang, Jeon;
- Choi, Jie-Won;
- 외 10명
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23Citations
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24초록
A series of hydroxybenzoxazole derivatives was synthesized, and their c-Met kinase inhibitory activity was evaluated. Described herein is a potent c-Met inhibitor by structural modification of the parent benzoxazole scaffold, with particular focus on the hydroxyl substituent of the benzoxazole moiety. (C) 2012 Elsevier Ltd. All rights reserved.
키워드
Cancer; c-Met kinase; Aminopyridine; Benzoxazole; SIGNALING PATHWAY; ACQUIRED-RESISTANCE; CANCER; TARGET
- 제목
- Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
- 저자
- Lee, Jongkook; Han, Sun-Young; Jung, Heejung; Yang, Jeon; Choi, Jie-Won; Chae, Chong Hack; Park, Chi Hoon; Choi, Sang Un; Lee, Kwangho; Du Ha, Jae; Lee, Chong Ock; Ryu, Jae Wook; Kim, Hyoung Rae; Koh, Jong Sung; Cho, Sung Yun
- 발행일
- 2012-06
- 유형
- Article
- 권
- 22
- 호
- 12
- 페이지
- 4044 ~ 4048