상세 보기
- Yang, Y.J.;
- Song, J.-H.;
- Yang, J.-H.;
- Kim, M.J.;
- Kim, K.Y.;
- ... Jin, Y.B.;
- ... Kim, W.H.;
- ... Kim, S.;
- ... Park, K.I.;
- ... Lee, H.-J.;
- 외 2명
WEB OF SCIENCE
4SCOPUS
7초록
Periodontitis is caused by pathogens in the oral cavity. It is a chronic infectious disease that causes symptoms including gingival bleeding and tooth loss resulting from the destruction of periodontal tissues coupled with inflammation. Dendropanax morbiferus H.Lév (DM) is a natural product that exhibits various biological activities with few side effects. In this study, the potential of DM leaf hot-water extracts (DMWE) as a treatment for periodontitis was determined and its anti-oxidant and anti-inflammatory effects were evaluated. Compounds in DMWE were identified by high-performance liquid chromatography (HPLC) and nitric oxide (NO) and prostaglandin E2 (PGE2) production was measured in RAW 264.7 cells. We measured the gingival index and gingival sulcus depth, and micro-CT was performed in vivo using a ligature-induced periodontitis rat model, which is similar to human periodontitis. The DMWE-treated group exhibited a decrease in cytokine concentration and relieved the gingival index and gingival sulcus depth compared with the periodontitis-induced control group. In addition, micro-CT and histological analysis revealed that DMWE exhibited anti-inflammatory effects and improved alveolar bone loss in periodontitis-induced rats. These findings suggest that DMWE has excellent anti-oxidant and anti-inflammatory effects that protect and prevent periodontal tissue damage and tooth loss caused by the inflammatory response. © 2023 by the authors.
키워드
- 제목
- Anti-Periodontitis Effects of Dendropanax morbiferus H.Lév Leaf Extract on Ligature-Induced Periodontitis in Rats
- 저자
- Yang, Y.J.; Song, J.-H.; Yang, J.-H.; Kim, M.J.; Kim, K.Y.; Kim, J.-K.; Jin, Y.B.; Kim, W.H.; Kim, S.; Kim, K.-R.; Park, K.I.; Lee, H.-J.
- 발행일
- 2023-01
- 유형
- Article
- 저널명
- Molecules
- 권
- 28
- 호
- 2