Comparative analysis of blood concentrations for orally administered micronized and non-micronized florfenicol in Sprague-Dawley rats

초록

Florfenicol is a fluorinated analog of thiamphenicol and has been used for the treatment of animal respiratory infectious diseases with a mechanism of action that inhibits bacterial protein synthesis. The aim of this study was conducted to investigate the effect of micronized and non-micronized-florfenicol prepared with different comminution techniques on the change in the blood concentration of florfenicol in rats. Forty adult male Sprague Dawley rats (6 weeks of age, body weight 126.8±9.52 g) were randomly allocated to two treatments groups: MF treated with micronized florfenicol powder (particle size,over 90% was 10 μm) and NMF treated with non-micronized florfenicol powder (particle size, over 70% was 100 μm) were given 97.5 mg/kg body weight once daily for four days. The results showed that MF at day 2, 3 (p<0.05) and 4 (p<0.001)had a significantly increased serum concentration of florfenicol compared to NMF. The results show that the micronization of florfenicol may provide higher oral bioavailability of the drug compared to its normal form.

키워드