상세 보기
- Kim, Bo-Gyu;
- Choi, Hoon Sik;
- Choe, Yong-ho;
- Jeon, Hyun Min;
- Heo, Ji Yeon;
- ... Cheon, Yun-Hong;
- ... Kang, Ki Mun;
- ... Lee, Sang-Il;
- ... Jeong, Bae Kwon;
- ... Kim, Mingyo
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4초록
Low-dose radiotherapy (LDRT) has been explored as a treatment option for various inflammatory diseases; however, its application in the context of rheumatoid arthritis (RA) is lacking. This study aimed to elucidate the mechanism underlying LDRT-based treatment for RA and standardize it. LDRT reduced the total numbers of immune cells, but increased the apoptotic CD4+ T and B220+ B cells, in the draining lymph nodes of collagen induced arthritis and K/BxN models. In addition, it significantly reduced the severity of various pathological manifestations, including bone destruction, cartilage erosion, and swelling of hind limb ankle. Post-LDRT, the proportion of apoptotic CD4+ T and CD19+ B cells increased significantly in the PBMCs derived from human patients with RA. LDRT showed a similar effect in fibroblast-like synoviocytes as well. In conclusion, we report that LDRT induces apoptosis in immune cells and fibro-blast-like synoviocytes, contributing to attenuation of arthritis.
키워드
- 제목
- Low-Dose Radiotherapy Attenuates Experimental Autoimmune Arthritis by Inducing Apoptosis of Lymphocytes and Fibroblast-Like Synoviocytes
- 저자
- Kim, Bo-Gyu; Choi, Hoon Sik; Choe, Yong-ho; Jeon, Hyun Min; Heo, Ji Yeon; Cheon, Yun-Hong; Kang, Ki Mun; Lee, Sang-Il; Jeong, Bae Kwon; Kim, Mingyo
- 발행일
- 2024-08
- 유형
- Article
- 저널명
- Immune Network
- 권
- 24
- 호
- 4
- 페이지
- 1 ~ 13