Cp*Co(III)-Catalyzed gamma-Selective C-H Allylation/Hydroamination Cascade for the Synthesis of Dihydroisoquinolines

초록

A Cp*Co(III)-catalyzed gamma-selective C-H allylation/hydroamination cascade toward the synthesis of 3,4-dihydroiSoquinolines (DHIQs) has been successfully developed, starting from NH ketimines and allyl carbonates. Notably, highly efficient and gamma-selective C-H allylations were accomplished using gamma-substituted allyl reagents, thus overcoming the issues of poor alpha/gamma selectivity and low reactivity of previous transition metal-catalyzed C-H allylations. The stereochemistry of allyl carbonates was a crucial factor, and synthesis of the DHIQs was achieved using (Z)-allyl carbonates.

키워드