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초록
The N121 site on the spike protein of SARS-CoV-2 is associated with heme and its metabolite, biliverdin, which can affect antibody binding. Both N121T and N121S substitutions have been observed in natural conditions and in a hamster model of dual infection with SARS-CoV-2 and Influenza A virus. Serum pseudotype neutralization assays against HIV-1 particles carrying wild-type, N121T, and N121S spikes with immune mouse and human sera revealed that N121T and N121S mutations had a greater impact on serum neutralization than biliverdin treatment. Although N121T and N121S substitutions are not currently major SARS-CoV-2 variants of concern, this study could provide fundamental information to prepare for potential future mutations at the N121 site of SARS-CoV-2. © 2024 Wiley Periodicals LLC.
키워드
- 제목
- N121T and N121S substitutions on the SARS-CoV-2 spike protein impact on serum neutralization
- 저자
- Lo, Van Thi; Lim, Hyun A.; Jang, Seong Sik; Kim, Min Chan; Chamfort, Alain Chrysler; Kim, Ha Yeon; Mun, Da Young; Kang, Min Chang; Lee, Han Byul; Kim, Sunjoo; Lee, Younghee; Park, Sangkyu; Yoon, Sun-Woo; Kim, Hye Kwon
- 발행일
- 2024-09
- 유형
- Article
- 권
- 96
- 호
- 9