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The multi-functional roles of forkhead box protein O in skin aging and diseases
- Moon, Kyoung Mi;
- Lee, Min-Kyeong;
- Hwang, Taehyeok;
- Choi, Chun Whan;
- Kim, Min Soo;
- 외 2명
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18초록
Forkhead box, class O (FoxO) family members are multifunctional transcription factors that are involved in several metabolic processes, including energy metabolism, apoptosis, DNA repair, and oxidative stress. However, their roles in skin health have not been well-documented. Recent studies have indicated that FoxOs are important factors to control skin homeostasis and health. The activation or deactivation of some FoxO family members is closely related to melanogenesis, wound healing, acne, and melanoma. In this review, we have discussed the recent findings that demonstrate the relationship between FoxOs and skin health as well as the underlying mechanisms associated with their functions.
키워드
FoxOs; Melanogenesis; Wound healing; Acne; Melanoma; TRANSCRIPTION FACTOR FOXO3A; ENDOTHELIAL GROWTH-FACTOR; MELANOMA-CELLS; OXIDATIVE STRESS; MAMMALIAN TARGET; POTENTIAL ROLE; ACNE-VULGARIS; TNF-ALPHA; FACTOR-I; EXPRESSION
- 제목
- The multi-functional roles of forkhead box protein O in skin aging and diseases
- 저자
- Moon, Kyoung Mi; Lee, Min-Kyeong; Hwang, Taehyeok; Choi, Chun Whan; Kim, Min Soo; Kim, Hyeung-Rak; Lee, Bonggi
- 발행일
- 2021-10
- 유형
- Article
- 저널명
- Redox Biology
- 권
- 46