Presentation and treatment of eosinophilic gastroenteritis in Busan and Gyeongnam, Korea: A multicenter study

초록

BACKGROUND Eosinophilic gastroenteritis (EGE) is a relatively rare disease characterized by eosinophilic infiltration of the gastrointestinal wall. Limited data are available regarding the clinical characteristics, treatment patterns, and outcomes of patients with EGE in Korea. AIM To investigate the clinical features, endoscopic findings, treatments, outcomes, and treatment response and relapse predictors in the abovementioned population. METHODS We retrospectively reviewed the medical records of 73 patients with histologically confirmed EGE in Busan and Gyeongnam, Korea, from 2010 to 2023. Clinical, endoscopic, laboratory, and treatment-related data were collected. RESULTS The median patient age was 52 years, and 50.7% of the patients were female. Of the patients, 35 had enterocolitis, 34 had gastroduodenitis, and four had gastroenterocolitis. Endoscopic abnormalities were observed in 82.2% of the patients. Proton pump inhibitors were prescribed primarily for gastroduodenitis, whereas corticosteroids were prescribed more frequently for enterocolitis and gastroenterocolitis. The clinical response rates were high for all groups (75.0%-90.3%); however, relapse occurred more frequently in patients with enterocolitis (43.3%). Male sex was associated with clinical response, although this association should be interpreted with caution; no significant predictors of relapse were identified. CONCLUSION Patients with EGE exhibit diverse clinical characteristics and treatment patterns. While the clinical response to primary treatment is relatively high, relapse is more common in patients with enterocolitis, indicating the need for location-based strategies and close follow-up.

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