노년기 남성에서 근감소증과 우울 발생의 연관성: 한국 노쇠 및 노화 코호트(KFACS) 연구

초록

Objective: To investigate the longitudinal association between sarcopenia and depressive symptoms in community-dwelling older adults, focusing on sex-specific differences. Methods: This 2-year prospective study utilized data from the Korean Frailty and Aging Cohort Study. We included 1,366 participants (700 men, 666 women) aged 70-84 years who were free of depressive symptoms (Short Geriatric Depression Scale- Korean [SGDS-K]<8) at baseline. Sarcopenia status (no sarcopenia, sarcopenia, severe sarcopenia) was defined by the Asian Working Group for Sarcopenia 2019 criteria. Multivariate logistic regression analysis was performed to assess the association between baseline sarcopenia and incident depressive symptoms (SGDS-K≥8) at follow-up, adjusting for covariates. Results: After adjustment, baseline severe sarcopenia was significantly associated with a higher risk of incident depression (adjusted odds ratio [aOR]=3.040, 95% confidence interval [CI]=1.494-6.188). In the sex-stratified analysis, this association remained robust only in men (aOR=3.344, 95% CI=1.332-8.395), but was not statistically significant in women (aOR=2.490, 95% CI=0.699-8.872, p=0.159). Conclusion: Severe sarcopenia independently predicts for 2-year development of depressive symptoms, particularly among older Korean men. These findings highlight a significant sex difference in the temporal relationship between sarcopenia and depression for older men.

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