Protective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage

Kang, Ki Sung; Kim, Hyun Young; Yoo, Hye Hyun; Piao, Xiang Lan; Ham, Jungyeob; Yang, Hyun Ok; Park, Jeong Hill

doi:10.1016/j.bmcl.2011.10.063

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Protective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage

Kang, Ki Sung;
Kim, Hyun Young;
Yoo, Hye Hyun;
Piao, Xiang Lan;
Ham, Jungyeob;
외 2명

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13

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17

초록

The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, Delta(20(21))-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of Delta(20(21))-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress. (C) 2011 Elsevier Ltd. All rights reserved.

키워드

Panax ginseng; Renoprotective activity; Ginsenoside; Sapogenin; RADICAL-SCAVENGING ACTIVITY; HEAT-PROCESSED GINSENG; DIABETIC-NEPHROPATHY; RENAL DAMAGE; GINSENOSIDES; OXYGEN; ANTIOXIDANT; REDUCTION; RATS; RB-1

제목: Protective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage

저자: Kang, Ki Sung; Kim, Hyun Young; Yoo, Hye Hyun; Piao, Xiang Lan; Ham, Jungyeob; Yang, Hyun Ok; Park, Jeong Hill

DOI: 10.1016/j.bmcl.2011.10.063

발행일: 2012-01-01

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 22

호: 1

페이지: 634 ~ 637

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 4 페이지

ISSN: E 1464-3405
P 0960-894X