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Development of a RuHAP-Packed-Bed Reactor for Continuous Flow Aerobic Oxidation
- Lee, Soocheon;
- Lee, Keunyoung;
- Kwon, Ki-Young;
- Kim, Hun Young;
- Oh, Kyungsoo
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0초록
The aerobic oxidation of alcohols is valuable but often limited by toxic reagents, waste, and harsh conditions. Using a Ru3+-hydroxyapatite (RuHAP)-packed-bed reactor under low-pressure O-2, we achieved efficient, reproducible oxidations with TONs of >18,000 after two catalyst regenerations. A two-step continuous flow process integrating oxidation and Knoevenagel condensation delivered products in excellent yields, demonstrating a scalable, safe, and sustainable method with high selectivity and mild conditions for fine chemical and pharmaceutical synthesis.
키워드
EFFICIENT HETEROGENEOUS OXIDATION; BOUND RU COMPLEX; SELECTIVE OXIDATION; ALCOHOLS; HYDROXYAPATITE; RUTHENIUM; CATALYSTS; NANOPARTICLES; SURFACE; BATCH
- 제목
- Development of a RuHAP-Packed-Bed Reactor for Continuous Flow Aerobic Oxidation
- 저자
- Lee, Soocheon; Lee, Keunyoung; Kwon, Ki-Young; Kim, Hun Young; Oh, Kyungsoo
- 발행일
- 2025-11
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 27
- 호
- 45
- 페이지
- 12536 ~ 12542