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초록
Dual Rh(II)/Pd(0) relay catalysis of N-sulfonyl triazoles and 2-hydroxymethylallyl carbonates has been developed, which affords N-sulfonyl pyrrolidines in moderate to good yields with high diastereoselectivities. The reaction proceeds via a relay mechanism involving O-H insertion onto the alpha-imino Rh(II)-carbene, [3,3]-sigmatropic rearrangement, dipole formation through Pd(0)-catalyzed decarboxylation, and intramolecular N-allylation, leading to the formation of multiple bonds in a one-pot operation.
키워드
BIMETALLIC CATALYSIS; ASYMMETRIC-SYNTHESIS; TERMINAL ALKYNES; CYCLOADDITION; ALKYLATION; FUNCTIONALIZATION; DERIVATIVES; ALLYLATION; TRANSITION; COMPLEXES
- 제목
- Dual Rh(II)/Pd(0) Relay Catalysis Involving Sigmatropic Rearrangement Using N-Sulfonyl Triazoles and 2-Hydroxymethylallyl Carbonates
- 저자
- Huang, Liang-Zhu; Xuan, Zi; Park, Jong-Un; Kim, Ju Hyun
- 발행일
- 2022-09
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 24
- 호
- 38
- 페이지
- 6951 ~ 6956