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Chemoselective synthesis of aryl(pyridinyl)methanol derivatives through Ni-NIXANTPHOS catalyzed alpha-arylation and tandem arylation/rearrangement of pyridylmethyl ethers
- 김병선;
- Liu, ZF (Liu, Zhengfen);
- Li, MY (Li, Minyan);
- Wang, BJ (Wang, Bijun);
- Deng, GG (Deng, Guogang);
- 외 4명
초록
An efficient synthesis of aryl(pyridyl)-methanol derivatives using a nickel-NIXANTPHOS catalyst is described. Combinations of the Ni-NIXANTPHOS catalyst, solvent, and reaction temperature achieved chemoselective arylation and tandem arylation/rearrangement of pyridylmethyl ethers. A large variety of aryl halides were tolerated (55 examples, up to 96% yield). The scalability of the reaction is demonstrated. The order of the tandem arylation and [1,2]-Wittig rearrangement was probed by comparative studies.
- 제목
- Chemoselective synthesis of aryl(pyridinyl)methanol derivatives through Ni-NIXANTPHOS catalyzed alpha-arylation and tandem arylation/rearrangement of pyridylmethyl ethers
- 저자
- 김병선; Liu, ZF (Liu, Zhengfen); Li, MY (Li, Minyan); Wang, BJ (Wang, Bijun); Deng, GG (Deng, Guogang); Chen, W (Chen, Wen); Zhang, HB (Zhang, Hongbin); Yang, XD (Yang, Xiaodong); Walsh, PJ (Walsh, Patrick J.)
- 발행일
- 2018-06
- 권
- 5
- 호
- 12
- 페이지
- 1870 ~ 1876
- 언어
- ENG
- 출판사
- ROYAL SOC CHEMISTRY
- 발행국가
- 영국
- 분량
- 7 페이지
- ISSN
- E 2052-4129
P 2052-4110