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Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.
- An, Joon Soo;
- Shin, Bora;
- Kim, Tae Ho;
- Hwang, Sunghoon;
- Shin, Yern-Hyerk;
- ... Jang, Jichan;
- 외 8명
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27초록
Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 mu M).
키워드
BIOSYNTHETIC GENE-CLUSTER; ABSOLUTE-CONFIGURATION; POLYKETIDE; SEQUENCE; NMR; HITACHIMYCIN; MECHANISM
- 제목
- Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.
- 저자
- An, Joon Soo; Shin, Bora; Kim, Tae Ho; Hwang, Sunghoon; Shin, Yern-Hyerk; Cui, Jinsheng; Du, Young Eun; Yi, Jungwoo; Nam, Sang-Jip; Hong, Suckchang; Shin, Jongheon; Jang, Jichan; Yoon, Yeo Joon; Oh, Dong-Chan
- 발행일
- 2021-05-07
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 23
- 호
- 9
- 페이지
- 3359 ~ 3363