Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.

An, Joon Soo; Shin, Bora; Kim, Tae Ho; Hwang, Sunghoon; Shin, Yern-Hyerk; Cui, Jinsheng; Du, Young Eun; Yi, Jungwoo; Nam, Sang-Jip; Hong, Suckchang; Shin, Jongheon; Jang, Jichan; Yoon, Yeo Joon; Oh, Dong-Chan

doi:10.1021/acs.orglett.1c00847

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Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.

An, Joon Soo;
Shin, Bora;
Kim, Tae Ho;
Hwang, Sunghoon;
Shin, Yern-Hyerk;
... Jang, Jichan;
외 8명

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21

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27

초록

Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 mu M).

키워드

BIOSYNTHETIC GENE-CLUSTER; ABSOLUTE-CONFIGURATION; POLYKETIDE; SEQUENCE; NMR; HITACHIMYCIN; MECHANISM

제목: Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.

저자: An, Joon Soo; Shin, Bora; Kim, Tae Ho; Hwang, Sunghoon; Shin, Yern-Hyerk; Cui, Jinsheng; Du, Young Eun; Yi, Jungwoo; Nam, Sang-Jip; Hong, Suckchang; Shin, Jongheon; Jang, Jichan; Yoon, Yeo Joon; Oh, Dong-Chan

DOI: 10.1021/acs.orglett.1c00847

발행일: 2021-05

유형: Article

저널명: Organic Letters

권: 23

호: 9

페이지: 3359 ~ 3363

언어: ENG

출판사: American Chemical Society

발행국가: 미국

분량: 5 페이지

ISSN: E 1523-7052
P 1523-7060