Intra-Articular Injection of Stem Cells for the Regeneration of Knee Joint Cartilage: a Therapeutic Option for Knee Osteoarthritis — a Narrative Review
  • Lee Hyun Jae
  • Hossain Rajib
  • Baek Chang-Heon
  • Lee Choong Jae
  • 황선철
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초록

Current approaches to regulating osteoarthritis primarily focus on symptom management; however, these methods often have significant side effects and may not be suitable for long-term care. As an alternative to conventional treatments, injecting stem cells into knee joint cartilage is a promising option for repairing damaged cartilage. In this review, we outline the general procedure for stem cell treatment of knee joint cartilage regeneration, emphasizing the potential of intra-articular stem cell injections as a therapeutic option for osteoarthritis. We examined and summarized patient evaluation and preparation for knee joint stem cell therapy, stem cell harvesting, stem cell preparation, injection procedures for stem cell therapy, post-injection care and monitoring, potential outcomes of stem cell therapy, and considerations and risks associated with stem cell therapy. Overall, stem cell injections for knee joint cartilage damage represent a promising frontier in orthopedic care. They offer potential benefits such as pain and inflammation reduction, promotion of cartilage repair and regeneration, and the possibility of avoiding more invasive treatments such as knee surgery. Ongoing collaboration among researchers, clinicians, and regulatory organizations is crucial for advancing this field and translating scientific discoveries into effective clinical applications.

키워드

OsteoarthritisCartilageStem cellsCULTURED ARTICULAR CHONDROCYTESPLATELET-RICH PLASMAGENE-EXPRESSIONMATRIX-METALLOPROTEINASEPROTEOLYTIC ACTIVITYMUC5AC MUCININ-VITROSECRETIONREPAIRBONE
제목
Intra-Articular Injection of Stem Cells for the Regeneration of Knee Joint Cartilage: a Therapeutic Option for Knee Osteoarthritis — a Narrative Review
저자
Lee Hyun JaeHossain RajibBaek Chang-HeonLee Choong Jae황선철
DOI
10.4062/biomolther.2024.139
발행일
2025-01
유형
Review
저널명
Biomolecules & Therapeutics
33
1
페이지
86 ~ 94