상세 보기
- Kim, Kyung-Ho;
- Joo, Min-Soo;
- Kang, Gyoungsik;
- Woo, Won-Sik;
- Sohn, Min-Young;
- ... Park, Chan-Il;
- 외 1명
WEB OF SCIENCE
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2초록
Interferon regulatory factors (IRFs) play crucial roles in antiviral processes, such as in the transcriptional induction of interferon (IFN) and IFN-stimulated genes (ISGs). In this study, the genes encoding IRF5 and IRF6 were identified in Pagrus major, and their expression in various organs after pathogen infection was analyzed. In the coding sequences of P. major (Pm)IRF5 and PmIRF6, the DNA binding domain, IRF association domain, and viral-activated domain were found to be highly conserved. Phylogenetic analysis revealed that PmIRF5 and PmIRF6 were most closely related to IRF5 and IRF6 of large yellow croakers. The mRNAs for PmIRF5 and PmIRF6 were constitutively expressed in all organs analyzed but were highly expressed in the liver and gills. As a result of an infection with red sea bream iridovirus, a major pathogen of red sea bream, PmIRF5 and PmIRF6 expression was significantly upregulated in the spleen and kidney. On the basis of these results, it can be concluded that IRF5 and IRF6 expression play an influential role in the immune system of red sea bream infected with viruses. © 2023 by the authors.
키워드
- 제목
- Characterization of Red Sea Bream (Pagrus major) Interferon Regulatory Factor 5 and 6 Genes and Their Expression in Response to RSIV Infection
- 저자
- Kim, Kyung-Ho; Joo, Min-Soo; Kang, Gyoungsik; Woo, Won-Sik; Sohn, Min-Young; Son, Ha-Jeong; Park, Chan-Il
- 발행일
- 2023-02
- 유형
- Article
- 저널명
- Fishes
- 권
- 8
- 호
- 2