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초록
An atom-economical strategy for the C-H alkenylation and C-H allylation of arenes by employing cyclopropenes as versatile alkenylating and allylating reagents is reported, catalyzed by cobalt. The Co-catalyzed C-H alkenylation process involves sequential C-H and C-C bond cleavage. Under the optimized conditions, broad-ranging alkenylated (hetero)arenes were synthesized with complete (E)-stereoselectivity (up to 91%). The consecutive C-H allylation proved viable under basic conditions via double-bond migration of the initially generated alkenyl (hetero)arenes, thus leading to allylated (hetero)arenes with high stereoselectivity of olefin (E/Z ratio = 91:9 to 100:0).
키워드
FUNCTIONALIZATION; ACCESS; ARENES
- 제목
- Co-III-Catalyzed C-H Alkenylation and Allylation with Cyclopropenes via Sequential C-H/C-C Bond Activation
- 저자
- Kim, Ye Lim; Park, Sun-a; Choi, Seoung-Mi; Park, Jong-Un; Kim, Ju Hyun
- 발행일
- 2021-09-03
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 23
- 호
- 17
- 페이지
- 6674 ~ 6679