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Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai
- La Kim, Eun;
- Li, Jian Lin;
- Dang, Hung The;
- Hong, Jongki;
- Lee, Chong-Ok;
- ... Kim, Euikyung;
- 외 4명
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43초록
Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereo-chemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC50 values in the range of 0.5-30 mu M. The cytochalasin B (5) showed obvious cytotoxicity with IC50 of 7.9 mu M against HeLa human cervical carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved.
키워드
Cytochalasin; Jellyfish-derived fungus; Phoma sp.; Nemopilema nomurai; Cytotoxicity; MARINE; CONFIGURATION
- 제목
- Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai
- 저자
- La Kim, Eun; Li, Jian Lin; Dang, Hung The; Hong, Jongki; Lee, Chong-Ok; Kim, Dong-Kyoo; Yoon, Won Duk; Kim, Euikyung; Liu, Yonghong; Jung, Jee H.
- 발행일
- 2012-05-01
- 유형
- Article
- 권
- 22
- 호
- 9
- 페이지
- 3126 ~ 3129