Synthetic Biology and Metabolic Engineering for Marine Carotenoids: New Opportunities and Future Prospects

Citations

WEB OF SCIENCE

33
Citations

SCOPUS

40

초록

Carotenoids are a class of diverse pigments with important biological roles such as light capture and antioxidative activities. Many novel carotenoids have been isolated from marine organisms to date and have shown various utilizations as nutraceuticals and pharmaceuticals. In this review, we summarize the pathways and enzymes of carotenoid synthesis and discuss various modifications of marine carotenoids. The advances in metabolic engineering and synthetic biology for carotenoid production are also reviewed, in hopes that this review will promote the exploration of marine carotenoid for their utilizations.

키워드

marine carotenoids; carotenoid synthesis; carotenoid modification; metabolic engineering; synthetic biology; protein engineering; NON-MEVALONATE PATHWAY; HIGH-LEVEL PRODUCTION; ESCHERICHIA-COLI; BETA-CAROTENE; BIOSYNTHETIC-PATHWAY; PHYTOENE DESATURASE; LYCOPENE PRODUCTION; FUNCTIONAL-ANALYSIS; DUNALIELLA-SALINA; SULFUR BACTERIA
제목
Synthetic Biology and Metabolic Engineering for Marine Carotenoids: New Opportunities and Future Prospects
저자
Wang, Chonglong; Kim, Jung-Hun; Kim, Seon-Won
DOI
10.3390/md12094810
발행일
2014-09
유형
Review
저널명
Marine Drugs
권
12
호
9
페이지
4810 ~ 4832