칼슘 흡수 증진소재로써 카제인 포스포펩타이드-키토올리고당 나노 복합체의 물리화학적 기능적 특성 연구
Physicochemical and Functional Properties of Casein Phosphopeptide–Chitosan Oligosaccharide Nanocomplexes as Calcium Absorption Enhancers

초록

Enhancing intestinal calcium absorption in the elderly is essential for reducing the risk of osteoporosis. The purpose of this study was to manufacture calcium-containing casein phosphopeptide (CPP)-chitosan oligosaccharide (CSO) nanocomplexes and determine their physicochemical properties (e.g., particle size) and functional characteristics (e.g., intestinal calcium absorption and entrapment efficiency). CPP-CSO nanocomplexes with particle sizes of less than 200 nm were successfully formed. The particle size of the CPP-CSO nanocomplexes increased with increasing CPP concentration, whereas their zeta potential value decreased. Increasing the pH from 5.5 to 6.6 led to a decrease in the particle size, and the zeta potential values decreased accordingly. Caco-2 cells exhibited no cytotoxicity at the various nanocomplex concentrations. The intestinal calcium absorption of the CPP-CSO nanocomplexes increased with a decrease in CPP concentration and an increase in pH. A negative correlation was found between calcium absorption and the particle size of CPP-CSO nanocomplexes. In conclusion, the CPP concentration and pH are manufacturing factors that affect the physicochemical properties of CPP-CSO nanocomplexes.

키워드

casein phosphopeptidechitosan oligosaccharidenanocomplexcalcium absorption
제목
칼슘 흡수 증진소재로써 카제인 포스포펩타이드-키토올리고당 나노 복합체의 물리화학적 기능적 특성 연구
제목 (타언어)
Physicochemical and Functional Properties of Casein Phosphopeptide–Chitosan Oligosaccharide Nanocomplexes as Calcium Absorption Enhancers
저자
이지홍임의성이원재
발행일
2025-12
유형
Y
저널명
Journal of Dairy Science and Biotechnology
43
4
페이지
267 ~ 276