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초록
An efficient tandem route to obtain tetrasubstituted NH pyrroles in a one-pot manner has been developed, staring from simple nitriles, ethyl bromoacetates, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of beta-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles in yields up to 91%.
키워드
tetrasubstituted pyrroles; nitriles; Blaise reaction; oxidative dimerization; tandem reaction; INTERMOLECULAR NITRENE TRANSFER; FORMAL 3+2 CYCLOADDITION; ONE-POT; POLYSUBSTITUTED PYRROLES; SUBSTITUTED PYRROLES; CASCADE REACTIONS; TERMINAL ALKYNES; CYCLIZATION; PYRROLIN-4-ONES; LAMELLARINS
- 제목
- Tandem Synthesis of Tetrasubstituted NH Pyrroles from Simple Nitriles
- 저자
- Kim, Hyeongsu; Xuan, Zi; Kim, Ju Hyun
- 발행일
- 2021-11-02
- 유형
- Article
- 권
- 16
- 호
- 21
- 페이지
- 3336 ~ 3340