Nicotinamide Improves Functional Recovery via Regulation of the RAGE/JNK/NF-kappa B Signaling Pathway after Brain Injury
DC Field | Value | Language |
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dc.contributor.author | Alam, Sayed Ibrar | - |
dc.contributor.author | Rehman, Shafiq Ur | - |
dc.contributor.author | Kim, Myeong Ok | - |
dc.date.accessioned | 2022-12-26T15:16:04Z | - |
dc.date.available | 2022-12-26T15:16:04Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2019-02 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/9486 | - |
dc.description.abstract | Brain injuries are a serious global health issue and are the leading cause of neurodegeneration. To date, there is no proper cure and treatment for brain-injury-induced neuropathological conditions because of a lack of sufficient knowledge and the failure to develop a drug due to the multi-pathological conditions in the brain. Herein, we explored the neurotherapeutic effects of Nicotinamide (NAM), against brain injury-induced neurodegeneration and behavioral problems. Treating injured mouse brains with NAM, for 7 days, significantly ameliorated several pathological events. Interestingly, NAM treatment significantly inhibited the injury-induced activation of receptor for advanced glycation end-products (RAGE), c-Jun N-terminal kinases (JNK), and neuroinflammatory mediators, such as NF-kappa B, TNF-alpha, IL-1 beta, and NOS2 in the brain, and it also regulated the levels of apoptotic markers, including Bax, caspase-3, and Bcl-2. Furthermore, treatment using NAM in TBI mice, significantly reversed synaptic protein loss and improved memory impairments and behavioral outcomes. Our findings suggested that NAM treatment reduced injury-induced secondary neurodegenerative pathology by modulating RAGE/JNK/NF-kappa B signaling in mice. Therefore, we recommend that NAM would be a safe and efficient therapeutic agent against brain-injury-induced neurodegeneration. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | MITOCHONDRIAL DYSFUNCTION | - |
dc.subject | COGNITIVE IMPAIRMENT | - |
dc.subject | ALZHEIMERS-DISEASE | - |
dc.subject | BETA PEPTIDE | - |
dc.subject | HEAD-INJURY | - |
dc.subject | CELL-DEATH | - |
dc.subject | NEUROINFLAMMATION | - |
dc.subject | RAGE | - |
dc.subject | ACTIVATION | - |
dc.title | Nicotinamide Improves Functional Recovery via Regulation of the RAGE/JNK/NF-kappa B Signaling Pathway after Brain Injury | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Ok | - |
dc.identifier.doi | 10.3390/jcm8020271 | - |
dc.identifier.scopusid | 2-s2.0-85064039257 | - |
dc.identifier.wosid | 000460295400144 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.8, no.2 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 8 | - |
dc.citation.number | 2 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | MITOCHONDRIAL DYSFUNCTION | - |
dc.subject.keywordPlus | COGNITIVE IMPAIRMENT | - |
dc.subject.keywordPlus | ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | BETA PEPTIDE | - |
dc.subject.keywordPlus | HEAD-INJURY | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | NEUROINFLAMMATION | - |
dc.subject.keywordPlus | RAGE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordAuthor | brain injury | - |
dc.subject.keywordAuthor | nicotinamide | - |
dc.subject.keywordAuthor | neurodegeneration | - |
dc.subject.keywordAuthor | synaptic dysfunction | - |
dc.subject.keywordAuthor | neuroinflammation | - |
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