Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairmentopen access
- Jang, Soomin; Han, Ji Won; Shin, Jiyoon; Kim, Tae Hui; Kwak, Kyung Phil; Kim, Kayoung; Kim, Bong Jo; Kim, Shin Gyeom; Kim, Jeong Lan; Kim, Tae Hyun; Moon, Seok Woo; Park, Jae Young; Park, Joon Hyuk; Byun, Seonjeong; Suh, Seung Wan; Seo, Jiyeong; So, Yoonseop; Ryu, Seung-Ho; Youn, Jong Chul; Lee, Kyoung Hwan; Lee, Dong Young; Lee, Dong Woo; Lee, Seok Bum; Lee, Jung Jae; Lee, Ju Ri; Jeong, Hyeon; Jeong, Hyun-Ghang; Jhoo, Jin Hyeong; Han, Kyuhee; Hong, Jong Woo; Kim, Ki Woong
- Issue Date
- KOREAN NEUROPSYCHIATRIC ASSOC
- Folate; Elderly; Cognition; Dementia; Cohort studies; Longitudinal studies
- PSYCHIATRY INVESTIGATION, v.16, no.7, pp.532 - 538
- Journal Title
- PSYCHIATRY INVESTIGATION
- Start Page
- End Page
- Objective This study aimed to examine the association between normal-but-low folate levels and cognitive function in the elderly population using a prospective cohort study. Methods We analyzed 3,910 participants whose serum folate levels were within the normal reference range (1.5-16.9 ng/mL) at baseline evaluation in the population-based prospective cohort study named the "Korean Longitudinal Study on Cognitive Aging and Dementia." The association between baseline folate quartile categories and baseline cognitive disorders [mild cognitive impairment (MCI) or dementia] was examined using binary logistic regression analysis adjusting for confounding variables. The risks of incident MCI and dementia associated with the decline of serum folate level during a 4-year follow-up period were examined using multinomial logistic regression analysis. Results The lowest quartile group of serum folate (>= 1.5, <= 5.9 ng/mL) showed a higher risk of cognitive disorders than did the highest quartile group at baseline evaluation (odds ratio 1.314, p=0.012). Over the 4 years of follow-up, the risk of incident dementia was 2.364 times higher among subjects whose serum folate levels declined from the 2nd-4th quartile group to the 1st quartile than among those for whom it did not (p=0.031). Conclusion Normal-but-low serum folate levels were associated with the risk of cognitive disorders in the elderly population, and a decline to normal-but-low serum folate levels was associated with incident dementia. Maintaining serum folate concentration above 5.9 ng/mL may be beneficial for cognitive status.
- Files in This Item
- There are no files associated with this item.
- Appears in
- College of Medicine > Department of Medicine > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.