Hypersensitivity Reactions to Iodinated Contrast Media: A Multicenter Study of 196081 Patients
DC Field | Value | Language |
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dc.contributor.author | Cha, Min Jae | - |
dc.contributor.author | Kang, Dong Yoon | - |
dc.contributor.author | Lee, Whal | - |
dc.contributor.author | Yoon, Soon Ho | - |
dc.contributor.author | Choi, Young Hun | - |
dc.contributor.author | Byun, Jun Soo | - |
dc.contributor.author | Lee, Jongmin | - |
dc.contributor.author | Kim, Yun-Hyeon | - |
dc.contributor.author | Choo, Ki Seok | - |
dc.contributor.author | Cho, Bum Sang | - |
dc.contributor.author | Jeon, Kyung Nyeo | - |
dc.contributor.author | Jung, Jae-Woo | - |
dc.contributor.author | Kang, Hye-Ryun | - |
dc.date.accessioned | 2022-12-26T14:33:00Z | - |
dc.date.available | 2022-12-26T14:33:00Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0033-8419 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/8720 | - |
dc.description.abstract | Background: Multicenter studies may be required for establishing guidelines for safe usage of iodinated contrast media (ICM). Purpose: To identify the prevalence, patterns, risk factors, and preventive measures for ICM-related hypersensitivity reactions (HSRs). Materials and Methods: Between March 2017 and October 2017, a total of 196 081 patients who underwent ICM administration were enrolled from seven participating institutions. The occurrence of HSRs and baseline patient information were recorded. chi(2) and Student t test were performed, and logistic regression analyses were used to identify risk factors that predict occurrence and recurrence of HSR. Results: Among 196 081 patients (mean age +/- standard deviation, 59.1 years +/- 16.0; 105 014 men and 91 067 women) who under-went ICM administration, the overall prevalence of HSRs was 0.73% (1433 of 196 081), and severe reactions occurred in 0.01% (17 of 196 081). Conditional logistic regression for patients with HSR (n = 1433) and a control group (1: 1 matched group for age, sex, ICM product, and institution) demonstrated that a patient's previous individual history of an ICM-related HSR (adjusted odds ratio [OR], 198.8; P < .001), hyperthyroidism (adjusted OR, 3.6; P = .04), drug allergy (adjusted OR, 3.5; P < .001), and other allergic diseases (adjusted OR, 6.8; P < .001) and a family history of ICM-related HSRs (adjusted OR, 14.0; P = .01) were predictors of HSR occurrence. Logistic regression analysis showed that use of premedication with antihistamine (OR, 0.5; P = .01) and change in the generic profile of ICM (OR, 0.5; P < .001) were preventive against recurrent HSR. Conclusion: Family history as well as previous individual history of hypersensitivity reactions (HSRs) to iodinated contrast media (ICM) were risk factors for HSR occurrence, suggesting a potential genetic predisposition. A change in the culprit ICM and premedication with antihistamine are useful for reducing the recurrence of HSRs. (C) RSNA, 2019 | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | RADIOLOGICAL SOC NORTH AMERICA | - |
dc.subject | ADVERSE-REACTIONS | - |
dc.subject | RISK-FACTORS | - |
dc.subject | PREMEDICATION | - |
dc.title | Hypersensitivity Reactions to Iodinated Contrast Media: A Multicenter Study of 196081 Patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeon, Kyung Nyeo | - |
dc.identifier.doi | 10.1148/radiol.2019190485 | - |
dc.identifier.scopusid | 2-s2.0-85072509475 | - |
dc.identifier.wosid | 000486623400019 | - |
dc.identifier.bibliographicCitation | RADIOLOGY, v.293, no.1, pp.117 - 124 | - |
dc.relation.isPartOf | RADIOLOGY | - |
dc.citation.title | RADIOLOGY | - |
dc.citation.volume | 293 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 117 | - |
dc.citation.endPage | 124 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | ADVERSE-REACTIONS | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | PREMEDICATION | - |
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