Chemokine receptor 4 (CXCR4) blockade enhances resistance to bacterial internalization in RAW264.7 cells and AMD3100, a CXCR4 antagonist, attenuates susceptibility to Brucella abortus 544 infection in a murine model
DC Field | Value | Language |
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dc.contributor.author | Reyes, Alisha Wehdnesday Bernardo | - |
dc.contributor.author | Arayan, Lauren Togonon | - |
dc.contributor.author | Tran Xuan Ngoc Huy | - |
dc.contributor.author | Vu, Son Hai | - |
dc.contributor.author | Kang, Chang Keun | - |
dc.contributor.author | Min, Wongi | - |
dc.contributor.author | Lee, Hu Jang | - |
dc.contributor.author | Lee, John Hwa | - |
dc.contributor.author | Kim, Suk | - |
dc.date.accessioned | 2022-12-26T14:32:39Z | - |
dc.date.available | 2022-12-26T14:32:39Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2019-10 | - |
dc.identifier.issn | 0378-1135 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/8699 | - |
dc.description.abstract | We investigated the involvement of chemokine receptor type 4 (CXCR4) signaling on the outcome of Brucella (B.) abortus 544 infection in murine macrophages and in a mouse model. CXCR4 manipulation were first evaluated for Brucella invasion and intracellular survival efficiency, mitogen-activated protein kinases (ERK1/2, JNK, p38a) activation and generation of nitric oxide (NO), and then in the splenic bacterial proliferation and cytokine production in BALB/c mice. CXCR4 blockade is involved in the successful control of Brucella invasion, reduction of ERK1/2 phosphorylation and inhibition of nitric oxide release from macrophages. Furthermore, using a reported CXCR4-specific antagonist AMD3100 resulted in splenomegaly but attenuated Brucella proliferation in these organs with elevated serum levels of MCP-1, TNF and IL-12. These findings provide insights on the contribution of CXCR4 signaling in the phagocytic pathway and immune modulation during B. abortus infection. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | CYTOKINE PRODUCTION | - |
dc.subject | EXPRESSION | - |
dc.subject | INDUCTION | - |
dc.subject | MACROPHAGES | - |
dc.subject | MICE | - |
dc.subject | IL-6 | - |
dc.title | Chemokine receptor 4 (CXCR4) blockade enhances resistance to bacterial internalization in RAW264.7 cells and AMD3100, a CXCR4 antagonist, attenuates susceptibility to Brucella abortus 544 infection in a murine model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Chang Keun | - |
dc.contributor.affiliatedAuthor | Lee, Hu Jang | - |
dc.contributor.affiliatedAuthor | Kim, Suk | - |
dc.identifier.doi | 10.1016/j.vetmic.2019.108402 | - |
dc.identifier.scopusid | 2-s2.0-85071970267 | - |
dc.identifier.wosid | 000491213800004 | - |
dc.identifier.bibliographicCitation | VETERINARY MICROBIOLOGY, v.237 | - |
dc.relation.isPartOf | VETERINARY MICROBIOLOGY | - |
dc.citation.title | VETERINARY MICROBIOLOGY | - |
dc.citation.volume | 237 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | IL-6 | - |
dc.subject.keywordAuthor | AMD3100 | - |
dc.subject.keywordAuthor | B. abortus | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | CXCR4 | - |
dc.subject.keywordAuthor | Invasion | - |
dc.subject.keywordAuthor | MAPKs | - |
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