Effects of dietary acetaminophen and vitamin C supplements on stress and inflammatory responses in Korean native cattle vaccinated with foot-and-mouth disease vaccine - a short communication

Abstract

This study evaluated the effect of a combination of acetaminophen and vitamin C (CAV) for reduction of stress and inflammatory responses in calves vaccinated with foot-and-mouth disease (FMD) vaccine. Twenty-five calves were divided into five groups of 5 calves. The negative control was non-vaccination and non-drug treatment. The positive control, and experimental groups I, II and III were vaccinated with FMD vaccine and treated with CAV at concentrations of 0.0, 0.5, 1.0 and 2.0 kg/ton feed, respectively, for five consecutive days post-vaccination. On day 5 post-treatment, serum cortisols and tumor necrosis factor-alpha (TNF-alpha) were significantly decreased in all treatment groups compared with the positive control (P<0.05). However, there was no significant difference in serum cortisol and TNF-alpha levels between experimental groups I and II and the negative control. The results from this study suggest that CAV may be a useful drug for control of the stress and inflammation caused by FMD vaccination in calves.