Cinnamomum verum extract as a potential therapeutic for atopic dermatitis through reducing lipid peroxidation and oxidative stress

Abstract

Background Oxidative stress and lipid peroxidation play crucial roles in the pathogenesis of atopic dermatitis (AD). Among the by-products of lipid peroxidation, 4-hydroxynonenal (4-HNE) is known to exacerbate inflammatory responses.Methods This study investigated the potential of Cinnamomum verum J. Presl. [Lauraceae] extract (CVE) in mitigating oxidative stress and suppressing 4-HNE-mediated inflammatory pathways in an AD model. The antioxidant properties of CVE were evaluated through lipid peroxidation assays, reactive oxygen species (ROS) measurement, and cytokine profiling.Results CVE treatment significantly reduced 4-HNE levels, decreased pro-inflammatory cytokine expression, and restored antioxidant enzyme activity.Conclusion These findings suggest that CVE may serve as a natural therapeutic agent for managing oxidative stress and inflammation in AD.