Controllable rheological properties of UV-responsive calix[4]arene gel for drug encapsulation and release

Abstract

This study investigates the potential of calix[4]arene-based supramolecular gels for use in drug delivery systems, focusing on both their rheological properties and controlled drug release behavior. We explore how key factors, including temperature, solvent exchange, and UV exposure, influence the gel's mechanical strength and its ability to encapsulate and release drugs. Specifically, our work examines how these external stimuli affect the stability of the gel matrix and modulate the release rate of the encapsulated drug. By systematically evaluating the effects of each factor, we aim to identify conditions that optimize drug release kinetics. The findings offer valuable insights into the development of a tunable, responsive platform for efficient drug delivery, highlighting the potential of calix[4]arene gels as promising candidates for advanced therapeutic applications.