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Rotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine

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dc.contributor.author이시준-
dc.contributor.author김문기-
dc.contributor.author원청길-
dc.date.accessioned2022-12-26T13:31:00Z-
dc.date.available2022-12-26T13:31:00Z-
dc.date.issued2020-
dc.identifier.issn2508-1357-
dc.identifier.issn2508-139X-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/7425-
dc.description.abstractDopamine (DA) receptor (D1 and D2-like receptors) agonists are known to affect expression levels of DA receptors. Rotigotine, a DA D2-like receptor agonist, has been developed for treating Parkinson’s disease (PD). However, its role in PD by acting through DA D2-like receptors has not been fully understood yet. The purpose of this study was to investigate neuroprotective effects of rotigotine through DA D2 and D3 receptors in 6-hydroxydopamine (6-OHDA) induced mouse model of PD. Expression level of tyrosine hydroxylase (TH) was examined using immunohistochemistry and Western blot analysis. Results revealed that unilateral injection of 6-OHDA into the midbrain caused significant loss of TH positive cells in the substantia nigra, whereas rotigotine inhibited such loss of TH cells in 6-OHDA-induced mouse model of PD. In vitro experiments demonstrated that rotigotine increased expression levels of TH against 6-OHDA-induced toxicity. The expression level of TH after treatment with L’741,626, a D2 receptor antagonist was decreased more than that after treatment with GR 103691, a D3 receptor antagonist. These results suggest that rotigotine can protect DA neurons against 6-OHDA induced toxicity and that the protective effect of rotigotine for DAergic neurons through a DA D2 receptor is stronger than that through a DA D3 receptor.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisher충북대학교 동물의학연구소-
dc.titleRotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine-
dc.title.alternativeRotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.bibliographicCitationJournal of Biomedical and Translational Research, v.21, no.4, pp 165 - 170-
dc.citation.titleJournal of Biomedical and Translational Research-
dc.citation.volume21-
dc.citation.number4-
dc.citation.startPage165-
dc.citation.endPage170-
dc.identifier.kciidART002666655-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasskci-
dc.subject.keywordAuthor6-hydroxydopamine-
dc.subject.keywordAuthordopamine D2 receptor-
dc.subject.keywordAuthorParkinson’s disease-
dc.subject.keywordAuthorrotigotine-
dc.subject.keywordAuthortyrosine hydroxylase-
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