Rotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이시준 | - |
dc.contributor.author | 김문기 | - |
dc.contributor.author | 원청길 | - |
dc.date.accessioned | 2022-12-26T13:31:00Z | - |
dc.date.available | 2022-12-26T13:31:00Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2508-1357 | - |
dc.identifier.issn | 2508-139X | - |
dc.identifier.uri | https://scholarworks.gnu.ac.kr/handle/sw.gnu/7425 | - |
dc.description.abstract | Dopamine (DA) receptor (D1 and D2-like receptors) agonists are known to affect expression levels of DA receptors. Rotigotine, a DA D2-like receptor agonist, has been developed for treating Parkinson’s disease (PD). However, its role in PD by acting through DA D2-like receptors has not been fully understood yet. The purpose of this study was to investigate neuroprotective effects of rotigotine through DA D2 and D3 receptors in 6-hydroxydopamine (6-OHDA) induced mouse model of PD. Expression level of tyrosine hydroxylase (TH) was examined using immunohistochemistry and Western blot analysis. Results revealed that unilateral injection of 6-OHDA into the midbrain caused significant loss of TH positive cells in the substantia nigra, whereas rotigotine inhibited such loss of TH cells in 6-OHDA-induced mouse model of PD. In vitro experiments demonstrated that rotigotine increased expression levels of TH against 6-OHDA-induced toxicity. The expression level of TH after treatment with L’741,626, a D2 receptor antagonist was decreased more than that after treatment with GR 103691, a D3 receptor antagonist. These results suggest that rotigotine can protect DA neurons against 6-OHDA induced toxicity and that the protective effect of rotigotine for DAergic neurons through a DA D2 receptor is stronger than that through a DA D3 receptor. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 충북대학교 동물의학연구소 | - |
dc.title | Rotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine | - |
dc.title.alternative | Rotigotine protects dopaminergic neurons through dopamine D2 receptor against 6-hydroxydopamine | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.bibliographicCitation | Journal of Biomedical and Translational Research, v.21, no.4, pp 165 - 170 | - |
dc.citation.title | Journal of Biomedical and Translational Research | - |
dc.citation.volume | 21 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 165 | - |
dc.citation.endPage | 170 | - |
dc.identifier.kciid | ART002666655 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | 6-hydroxydopamine | - |
dc.subject.keywordAuthor | dopamine D2 receptor | - |
dc.subject.keywordAuthor | Parkinson’s disease | - |
dc.subject.keywordAuthor | rotigotine | - |
dc.subject.keywordAuthor | tyrosine hydroxylase | - |
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