Lumbosacral polyradiculoneuropathy associated with combination therapy of nivolumab and ipilimumab

Abstract

Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising therapeutic options for advanced cancers. While ICIs have improved survival in multiple cancers, their in- creased use is restricted by various immune-related adverse events. In this report we describe a patient with renal cell carcinoma who received a combination of ICIs, nivolumab plus ipilim- umab, and who developed lumbosacral polyradiculoneuropathy. Corticosteroid use was an effective treatment for this patient.