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용해도가 개선된 티카그렐러 고체분산체 함유 정제의 개발Development of a Novel Ticagrelor Solid Dispersion-loaded Tablet with Enhanced Solubility

Other Titles
Development of a Novel Ticagrelor Solid Dispersion-loaded Tablet with Enhanced Solubility
Authors
최형주김경수
Issue Date
2020
Publisher
대한약학회
Keywords
ticagrelor; solid dispersion; tablet; solubility; dissolution
Citation
약 학 회 지, v.64, no.1, pp 21 - 27
Pages
7
Indexed
KCI
Journal Title
약 학 회 지
Volume
64
Number
1
Start Page
21
End Page
27
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/7255
DOI
10.17480/psk.2020.64.1.21
ISSN
0377-9556
2383-9457
Abstract
The objective of this study was to develop a novel ticagrelor (TC) solid dispersion-loaded tablet with enhancedsolubility. Numerous polymers and surfactant were screened, and then Kollidon VA64 and Poloxamer 407 were selectedas a soluble polymer and a surfactant for preparing TC solid dispersions. Various solid dispersions were prepared by spraydryingprocess, and the physicochemical properties, solubility and dissolution profile were investigated. The TC soliddispersion consisted of TC, Kollidon VA64, Poloxamer 407 and colloidal silica at a weight ratio of 1/1/4/1, provided anamorphous drug and spherical particle shape. Moreover, it exhibited excellent solubility and dissolution rate compared tothe TC. The TC solid dispersion-loaded tablet were prepared and their dissolution were evaluated compared to commercialTC tablet. The required time for complete release of the TC solid dispersion and the TC solid dispersion-loaded tabletwere within 60 min and 8 hrs in various dissolution media. However commercial TC tablets showed low dissolution rateless than 10% in pH 1.2, 4.0 and 6.8 buffer up to 8 hrs. Thus, we successfully prepared the TC solid dispersion-loadedtablet for enhancing solubility of TC and this novel TC solid dispersion-loaded tablet could be a potential alternative forcommercial TC tablet.
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자연과학대학 > Department of Pharmaceutical Engineering > Journal Articles

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자연과학대학 (제약공학과)
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