Malignant Peripheral Nerve Sheath Tumour in the Urinary Bladder of a Dog

Abstract

A 15-year-old neutered male miniature pinscher was presented with a pedunculated mass (4 x 1 cm) in its urinary bladder. Exploratory cystotomy revealed that the mass was located at the trigone of the bladder and projected into the lumen. The cut surface of the mass was homogeneous grey to tan in colour with focal brown pigmentation. Microscopically, the mass was predominantly composed of neoplastic spindle cells characterized by moderate cellular pleomorphism, invasion into the muscular layer of the bladder wall and few mitotic figures. The neoplastic spindle cells formed interwoven bundles intersecting at various angles. Immunohisto-chemically, these cells were negative for cytokeratin 7 and alpha-smooth muscle actin, but strongly expressed 5100 and vimentin, confirming a diagnosis of a malignant peripheral nerve sheath tumour (PNST). To the best of our knowledge, this is the first report of a primary malignant PNST in the urinary bladder of a dog. (C) 2019 Elsevier Ltd. All rights reserved.