Artemisia annua L. Polyphenols Enhance the Anticancer Effect of β-Lapachone in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells
DC Field | Value | Language |
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dc.contributor.author | Jung, Eun Joo | - |
dc.contributor.author | Kim, Hye Jung | - |
dc.contributor.author | Shin, Sung Chul | - |
dc.contributor.author | Kim, Gon Sup | - |
dc.contributor.author | Jung, Jin-Myung | - |
dc.contributor.author | Hong, Soon Chan | - |
dc.contributor.author | Kim, Choong Won | - |
dc.contributor.author | Lee, Won Sup | - |
dc.date.accessioned | 2024-01-11T02:00:37Z | - |
dc.date.available | 2024-01-11T02:00:37Z | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.issn | 1422-0067 | - |
dc.identifier.uri | https://scholarworks.gnu.ac.kr/handle/sw.gnu/69197 | - |
dc.description.abstract | Recent studies suggest that the anticancer activity of β-lapachone (β-Lap) could be improved by different types of bioactive phytochemicals. The aim of this study was to elucidate how the anticancer effect of β-Lap is regulated by polyphenols extracted from Korean Artemisia annua L. (pKAL) in parental HCT116 and oxaliplatin-resistant (OxPt-R) HCT116 colorectal cancer cells. Here, we show that the anticancer effect of β-Lap is more enhanced by pKAL in HCT116-OxPt-R cells than in HCT116 cells via a CCK-8 assay, Western blot, and phase-contrast microscopy analysis of hematoxylin-stained cells. This phenomenon was associated with the suppression of OxPt-R-related upregulated proteins including p53 and β-catenin, the downregulation of cell survival proteins including TERT, CD44, and EGFR, and the upregulation of cleaved HSP90, γ-H2AX, and LC3B-I/II. A bioinformatics analysis of 21 proteins regulated by combined treatment of pKAL and β-Lap in HCT116-OxPt-R cells showed that the enhanced anticancer effect of β-Lap by pKAL was related to the inhibition of negative regulation of apoptotic process and the induction of DNA damage through TERT, CD44, and EGFR-mediated multiple signaling networks. Our results suggest that the combination of pKAL and β-Lap could be used as a new therapy with low toxicity to overcome the OxPt-R that occurred in various OxPt-containing cancer treatments. © 2023 by the authors. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.title | Artemisia annua L. Polyphenols Enhance the Anticancer Effect of β-Lapachone in Oxaliplatin-Resistant HCT116 Colorectal Cancer Cells | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/ijms242417505 | - |
dc.identifier.scopusid | 2-s2.0-85180679209 | - |
dc.identifier.wosid | 001132399700001 | - |
dc.identifier.bibliographicCitation | International Journal of Molecular Sciences, v.24, no.24 | - |
dc.citation.title | International Journal of Molecular Sciences | - |
dc.citation.volume | 24 | - |
dc.citation.number | 24 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | PHASE-III | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordAuthor | anticancer effect | - |
dc.subject.keywordAuthor | Artemisia annua L. polyphenols | - |
dc.subject.keywordAuthor | chemotherapy | - |
dc.subject.keywordAuthor | colorectal cancer | - |
dc.subject.keywordAuthor | oxaliplatin-resistant | - |
dc.subject.keywordAuthor | phytochemical | - |
dc.subject.keywordAuthor | β-lapachone | - |
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