치료 경험이 없는 당뇨황반부종 환자에서 유리체강 내 라니비주맙 주입술의 단기 효과

Abstract

Purpose: To evaluate the clinical outcomes of treatment-naïve patients with diabetic macular edema (DME) treated with intravitreal ranibizumab injections. Methods: This study included 25 eyes in 21 DME patients who had received no previous treatment. The patients were divided into two groups, loading and non-loading groups. The loading group was treated with 3 consectutive monthly intravitreal ranibizumab injections, and the non-loading group was treated pro re nata. The best corrected visual acuity and central retinal thickness were compared after intravitreal ranibizumab injections. Patients were also divided into the responsive and the limited responsive groups according to the effect of treatment and analyzed retrospectively. Results: The central retinal thickness decreased after intravitreal injections in both the loading and the non-loading groups, and the change was statistically significant 7 months after treatment. The final central retinal thickness was significantly lower in the responsive group. The proportion of the loading group in the responsive group was significantly higher than that of limited responsive group. Conclusions: Intravitreal ranibizumab injection is a useful treatment for a short-term improvement of DME, especially in the loading group, but a long-term follow-up also should be considered.