Adenosine receptor Adora2b antagonism attenuates Brucella abortus 544 infection in professional phagocyte RAW 264.7 cells and BALB/c mice
DC Field | Value | Language |
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dc.contributor.author | Reyes, Alisha Wehdnesday Bernardo | - |
dc.contributor.author | Vu, Son Hai | - |
dc.contributor.author | Huy, Tran Xuan Ngoc | - |
dc.contributor.author | Min, Wongi | - |
dc.contributor.author | Lee, Hu Jang | - |
dc.contributor.author | Chang, Hong Hee | - |
dc.contributor.author | Lee, John Hwa | - |
dc.contributor.author | Kim, Suk | - |
dc.date.accessioned | 2022-12-26T13:01:59Z | - |
dc.date.available | 2022-12-26T13:01:59Z | - |
dc.date.created | 2022-12-12 | - |
dc.date.issued | 2020-03 | - |
dc.identifier.issn | 0378-1135 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/6862 | - |
dc.description.abstract | Brucella as a stealthy intracellular pathogen avoids activation of innate immune response. Here we investigated the contribution of an adenosine receptor, Adora2b, during Brucella infection in professional phagocyte RAW 264.7 cells and in a murine model. Adora2b-deficient cells showed attenuated Brucella internalization and intracellular survival with enhanced release of IL-6, TNF-alpha, IL-12 and MCP-1. In addition, blockade of Adora2b using MRS 1754 treatment in mice resulted in increased total weight of the spleens but suppressed bacterial burden in these organs accompanied by elevated levels of IL-6, IFN-gamma, TNF-alpha, IL-12 and MCP-1, while reduced IL-10. Overall, we proposed that the Adora2b participates in the successful phagocytic pathway and intracellular survival of Brucella in RAW 264.7 cells, and could be a potential therapeutic target for the treatment of acute brucellosis in animals. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | IMMUNITY | - |
dc.subject | VACCINE | - |
dc.title | Adenosine receptor Adora2b antagonism attenuates Brucella abortus 544 infection in professional phagocyte RAW 264.7 cells and BALB/c mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Wongi | - |
dc.contributor.affiliatedAuthor | Lee, Hu Jang | - |
dc.contributor.affiliatedAuthor | Chang, Hong Hee | - |
dc.contributor.affiliatedAuthor | Kim, Suk | - |
dc.identifier.doi | 10.1016/j.vetmic.2020.108586 | - |
dc.identifier.scopusid | 2-s2.0-85078557628 | - |
dc.identifier.wosid | 000521515200012 | - |
dc.identifier.bibliographicCitation | VETERINARY MICROBIOLOGY, v.242 | - |
dc.relation.isPartOf | VETERINARY MICROBIOLOGY | - |
dc.citation.title | VETERINARY MICROBIOLOGY | - |
dc.citation.volume | 242 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | VACCINE | - |
dc.subject.keywordAuthor | Adora2b | - |
dc.subject.keywordAuthor | Brucella abortus | - |
dc.subject.keywordAuthor | Cytokines | - |
dc.subject.keywordAuthor | Macrophages | - |
dc.subject.keywordAuthor | Spleen | - |
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