Polyphenols Extracted from Artemisia annua L. Exhibit Anti-Cancer Effects on Radio-Resistant MDA-MB-231 Human Breast Cancer Cells by Suppressing Stem Cell Phenotype, beta-Catenin, and MMP-9
DC Field | Value | Language |
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dc.contributor.author | Ko, Young Shin | - |
dc.contributor.author | Jung, Eun Joo | - |
dc.contributor.author | Go, Se-il | - |
dc.contributor.author | Jeong, Bae Kwon | - |
dc.contributor.author | Kim, Gon Sup | - |
dc.contributor.author | Jung, Jin-Myung | - |
dc.contributor.author | Hong, Soon Chan | - |
dc.contributor.author | Kim, Choong Won | - |
dc.contributor.author | Kim, Hye Jung | - |
dc.contributor.author | Lee, Won Sup | - |
dc.date.accessioned | 2022-12-26T12:48:16Z | - |
dc.date.available | 2022-12-26T12:48:16Z | - |
dc.date.created | 2022-12-12 | - |
dc.date.issued | 2020-04-02 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/6728 | - |
dc.description.abstract | Artemisia annua L. has been reported to show anti-cancer activities. Here, we determined whether polyphenols extracted from Artemisia annua L. (pKAL) exhibit anti-cancer effects on radio-resistant MDA-MB-231 human breast cancer cells (RT-R-MDA-MB-231 cells), and further explored their molecular mechanisms. Cell viability assay and colony-forming assay revealed that pKAL inhibited cell proliferation on both parental and RT-R-MDA-MB-231 cells in a dose-dependent manner. The anti-proliferative effects of pKAL on RT-R-MDA-MB-231 cells were superior or similar to those on parental ones. Western blot analysis revealed that expressions of cluster of differentiation 44 (CD44) and Oct 3/4, matrix metalloproteinase-9 (MMP-9) and signal transducer and activator of transcription-3 (STAT-3) phosphorylation were significantly increased in RT-R-MDA-MB-231 cells compared to parental ones, suggesting that these proteins could be associated with RT resistance. pKAL inhibited the expression of CD44 and Oct 3/4 (CSC markers), and beta-catenin and MMP-9 as well as STAT-3 phosphorylation of RT-R-MDA-MB-231. Regarding upstream signaling, the JNK or JAK2 inhibitor could inhibit STAT-3 activation in RT-R-MDA-MB-231 cells, but not augmented pKAL-induced anti-cancer effects. These findings suggest that c-Jun N-terminal kinase (JNK) or Janus kinase 2 (JAK2)/STAT3 signaling are not closely related to the anti-cancer effects of pKAL. In conclusion, this study suggests that pKAL exhibit anti-cancer effects on RT-R-MDA-MB-231 cells by suppressing CD44 and Oct 3/4, beta-catenin and MMP-9, which appeared to be linked to RT resistance of RT-R-MDA-MB-231 cells. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject | RADIATION-RESISTANCE | - |
dc.subject | SELF-RENEWAL | - |
dc.subject | EXPRESSION | - |
dc.subject | GROWTH | - |
dc.subject | GENERATION | - |
dc.subject | CD44 | - |
dc.subject | SOX2 | - |
dc.title | Polyphenols Extracted from Artemisia annua L. Exhibit Anti-Cancer Effects on Radio-Resistant MDA-MB-231 Human Breast Cancer Cells by Suppressing Stem Cell Phenotype, beta-Catenin, and MMP-9 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jeong, Bae Kwon | - |
dc.contributor.affiliatedAuthor | Kim, Gon Sup | - |
dc.contributor.affiliatedAuthor | Jung, Jin-Myung | - |
dc.contributor.affiliatedAuthor | Kim, Hye Jung | - |
dc.contributor.affiliatedAuthor | Lee, Won Sup | - |
dc.identifier.doi | 10.3390/molecules25081916 | - |
dc.identifier.scopusid | 2-s2.0-85083772432 | - |
dc.identifier.wosid | 000534617300085 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.25, no.8 | - |
dc.relation.isPartOf | MOLECULES | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 25 | - |
dc.citation.number | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | RADIATION-RESISTANCE | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | CD44 | - |
dc.subject.keywordPlus | SOX2 | - |
dc.subject.keywordAuthor | breast cancer cells | - |
dc.subject.keywordAuthor | polyphenols | - |
dc.subject.keywordAuthor | Artemisia annua L. | - |
dc.subject.keywordAuthor | stem cells | - |
dc.subject.keywordAuthor | EMT | - |
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