IL-17A treatment influences murine susceptibility to experimental Riemerella anatipestifer infection
- Cammayo, Paula Leona T.; Fernandez-Colorado, Cherry P.; Flores, Rochelle A.; Roy, Anindita; Kim, Suk; Lillehoj, Hyun S.; Kim, Woo H.; Min, Wongi
- Issue Date
- ELSEVIER SCI LTD
- Riemerella infection; Mouse model; IL-17A; IL-23; Susceptibility; Ducks
- DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, v.106
- Journal Title
- DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
- Riemerella anatipestifer causes infectious disease and considerable economic loss in the duck industry worldwide. Our previous studies demonstrated an association between proinflammatory cytokine interleukin (IL)-17A and R. anatipestifer infection. Here, we provide evidence for IL-17A involvement in R. anatipestifer infection using a mouse model. Mice showed higher resistance to R. anatipestifer infection than ducks, with median lethal doses (LD50) of 3.5 x 10(10) and 5 x 10(7) colony-forming units (CFU), respectively. Twenty-four hours after infection, mice with a sub-lethal dose (3.5 x 10(9) CFU) exhibited levels of IL-17A and IL-23 expression similar to uninfected mice. Thus, we hypothesized that exogenous IL-17A or IL-23 administration affects susceptibility of mice to R. anatipestifer. Mice pretreated with IL-17A or IL-23 prior to sub-lethal dose infection of R. anatipestifer exhibited increased bacterial burden and spleen weights compared to untreated infected mice, confirming the involvement of IL-17A in susceptibility to R. anatipestifer infection in vivo.
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- 수의과대학 > Department of Veterinary Medicine > Journal Articles
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