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PRDX4 overexpression is associated with poor prognosis in gastric cancer

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dc.contributor.authorPark, Sun Yi-
dc.contributor.authorLee, Young-Joon-
dc.contributor.authorPark, Jiho-
dc.contributor.authorKim, Tae-Han-
dc.contributor.authorHong, Soon-Chan-
dc.contributor.authorJung, Eun-Jung-
dc.contributor.authorJu, Young-Tae-
dc.contributor.authorJeong, Chi-Young-
dc.contributor.authorPark, Hee Jin-
dc.contributor.authorKo, Gyung Hyuck-
dc.contributor.authorSong, Dae Hyun-
dc.contributor.authorPark, Miyeong-
dc.contributor.authorYoo, Jiyun-
dc.contributor.authorJeong, Sang-Ho-
dc.date.accessioned2022-12-26T12:47:41Z-
dc.date.available2022-12-26T12:47:41Z-
dc.date.issued2020-05-
dc.identifier.issn1792-1074-
dc.identifier.issn1792-1082-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/6669-
dc.description.abstractPeroxiredoxin IV (PRDX4) is a multifunctional protein that is involved in cell protection against oxidative injury, regulation of cell proliferation, modulation of intracellular signaling, and the pathogenesis of tumors. We previously conducted a proteomic analysis to investigate tumor-specific protein expression in gastric cancer. The aim of the present study was to investigate whether PRDX4 could be a marker of poor prognosis in patients with gastric cancer. Immunohistochemistry was used to validate PRDX4 as a prognostic marker for gastric cancer. Short hairpin RNA (shRNA)-mediated knockdown of PRDX4 expression in AGS cells and MKN28 cells was used for functional studies, and PRDX4 overexpression in PRDX4-depleted cells was used for knock-in studies. Based on immunohistochemistry data, TNM stage and PRDX4 were independent prognostic factors in the Cox proportional hazard model (P<0.05). In the survival analysis, the PRDX4-overexpressing group demonstrated significantly worse survival than the PRDX4-underexpression group (P<0.01). In vitro, knockdown of PRDX4 expression by shRNA caused a significant decrease in cancer invasion. Conversely, overexpression of PRDX4 in PRDX4-depleted cancer cells promoted migration and invasion. By measuring the expression of EMT-related genes, we found that E-cadherin was increased in shPRDX4 cells compared with control shMKN28 cells, and snail and slug were decreased in shPRDX4-1 cells compared with sh-control cells. Furthermore, the expression levels of these genes could be recovered in rescue experiments. In conclusion, the results of the present study suggested that PRDX4 is a marker of poor prognosis in gastric cancer and that PRDX4 is associated with cancer cell migration and invasion via EMT.-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.publisherSPANDIDOS PUBL LTD-
dc.titlePRDX4 overexpression is associated with poor prognosis in gastric cancer-
dc.typeArticle-
dc.publisher.location그리이스-
dc.identifier.doi10.3892/ol.2020.11468-
dc.identifier.scopusid2-s2.0-85082778572-
dc.identifier.wosid000528714800018-
dc.identifier.bibliographicCitationONCOLOGY LETTERS, v.19, no.5, pp 3522 - 3530-
dc.citation.titleONCOLOGY LETTERS-
dc.citation.volume19-
dc.citation.number5-
dc.citation.startPage3522-
dc.citation.endPage3530-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaOncology-
dc.relation.journalWebOfScienceCategoryOncology-
dc.subject.keywordPlusPEROXIREDOXINS-
dc.subject.keywordPlusMECHANISMS-
dc.subject.keywordPlusCHEMOTHERAPY-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordAuthorstomach neoplasm-
dc.subject.keywordAuthorperoxiredoxin IV-
dc.subject.keywordAuthorbiomarkers-
dc.subject.keywordAuthorprognosis-
dc.subject.keywordAuthorsurvival analysis-
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