Modulatory Effect of Linoleic Acid During Brucella abortus 544 Infection in Murine Macrophage RAW264.7 Cells and Murine Model BALB/c Mice
DC Field | Value | Language |
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dc.contributor.author | Reyes, Alisha Wehdnesday Bernardo | - |
dc.contributor.author | Vu, Son Hai | - |
dc.contributor.author | Tran Xuan Ngoc Huy | - |
dc.contributor.author | Min, Wongi | - |
dc.contributor.author | Lee, Hu Jang | - |
dc.contributor.author | Chang, Hong Hee | - |
dc.contributor.author | Lee, John Hwa | - |
dc.contributor.author | Kim, Suk | - |
dc.date.accessioned | 2022-12-26T12:47:36Z | - |
dc.date.available | 2022-12-26T12:47:36Z | - |
dc.date.created | 2022-12-12 | - |
dc.date.issued | 2020-05 | - |
dc.identifier.issn | 1017-7825 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/6660 | - |
dc.description.abstract | In this study, we investigated the effects of linoleic acid (LA) treatment on Brucella abortus infection in professional phagocyte RAW264.7 cells, particularly during the pathogen's invasion and intracellular growth in these cells, as well as in murine model BALB/c mice focusing on bacterial splenic proliferation and immunoregulatory activities. LA inhibited the growth of Brucella in a dose- and time-dependent manner. The ability of the pathogen to enter the phagocytes was inhibited as was its survival within these cells. This was accompanied by increased nitrite accumulation in these cells at 24 h post-infection. The concentration of LA used in the present study did not affect the total body weight or liver function of the mice. During Brucella infection, the total splenic weight of these animals was not changed; rather, resistance to bacterial proliferation was enhanced in the spleen. Furthermore, mice treated with LA displayed elevated levels of IL-12 and IFN-gamma but reduced levels of IL-10 during infection. The findings in this study showed the regulatory role of LA against B. abortus infection suggesting its potential use in designing intervention strategy for brucellosis. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY | - |
dc.subject | NITRIC-OXIDE PRODUCTION | - |
dc.subject | ANTIBACTERIAL ACTIVITY | - |
dc.subject | FATTY-ACIDS | - |
dc.subject | IMMUNE | - |
dc.subject | EXPRESSION | - |
dc.subject | GAMMA | - |
dc.title | Modulatory Effect of Linoleic Acid During Brucella abortus 544 Infection in Murine Macrophage RAW264.7 Cells and Murine Model BALB/c Mice | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Min, Wongi | - |
dc.contributor.affiliatedAuthor | Lee, Hu Jang | - |
dc.contributor.affiliatedAuthor | Chang, Hong Hee | - |
dc.contributor.affiliatedAuthor | Kim, Suk | - |
dc.identifier.doi | 10.4014/jmb.1911.11037 | - |
dc.identifier.scopusid | 2-s2.0-85085905290 | - |
dc.identifier.wosid | 000541152700002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, v.30, no.5, pp.642 - 648 | - |
dc.relation.isPartOf | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.title | JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | - |
dc.citation.volume | 30 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 642 | - |
dc.citation.endPage | 648 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002588869 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | NITRIC-OXIDE PRODUCTION | - |
dc.subject.keywordPlus | ANTIBACTERIAL ACTIVITY | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | IMMUNE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GAMMA | - |
dc.subject.keywordAuthor | Brucella abortus | - |
dc.subject.keywordAuthor | cytokines | - |
dc.subject.keywordAuthor | invasion | - |
dc.subject.keywordAuthor | linoleic acid | - |
dc.subject.keywordAuthor | spleen weight | - |
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