The effect of Absolute Neutrophil Count (ANC) on early surgical site infection in Implanted Central Venous Catheter (ICVC)

Abstract

Purpose: The aim of this study was to evaluate surgical site infection (SSI) rates related to implanted central venous catheters (ICVC) in pediatric hematology and oncology patients with respect to absolute neutrophil count (ANC) levels. Patients and methods: From January 2004 to December 2015, pediatric patients with ICVC insertion were inves-tigated retrospectively. Patients were divided into four groups according to preoperative ANC levels and Granulocyte-colony stimulating factor (G-CSF) usage. Immediate and early surgical site infections were evaluated 7 and 30 days following surgery. Results: In total, 1143 patients were enrolled. Patients were placed into 4 groups: 930 patients in group 1 with an ANC >= 500/mu L without G-CSF, 149 in group 2 with an ANC >= 500/mu L after G-CSF usage, 36 in group 3 with an ANC <500/mu L without G-CSF, and 28 in group 4 with an ANC<500/mu L even after G-CSF administration. Rates of immediate and early SSIs were not statistically different between groups. In the two-group analysis (group 1 and 2 vs. 3 and 4), the number of immediate and early SS1s were not also different, respectively. Conclusion: There was no correlation between ANC levels and immediate and early 551 occurrence after ICVC placement. (C) 2020 Published by Elsevier B.V.