Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against A & beta;-Induced Neurodegeneration and Memory Impairment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Khan, Amjad | - |
dc.contributor.author | Park, Jun Sung | - |
dc.contributor.author | Kang, Min Hwa | - |
dc.contributor.author | Lee, Hyeon Jin | - |
dc.contributor.author | Ali, Jawad | - |
dc.contributor.author | Tahir, Muhammad | - |
dc.contributor.author | Choe, Kyonghwan | - |
dc.contributor.author | Kim, Myeong Ok | - |
dc.date.accessioned | 2023-07-07T05:41:09Z | - |
dc.date.available | 2023-07-07T05:41:09Z | - |
dc.date.created | 2023-07-07 | - |
dc.date.issued | 2023-06-01 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.gnu.ac.kr/handle/sw.gnu/59724 | - |
dc.description.abstract | Oxidative stress plays an important role in cognitive dysfunctions and is seen in neurodegeneration and Alzheimer's disease (AD). It has been reported that the polyphenolic compound caffeic acid possesses strong neuroprotective and antioxidant effects. The current study was conducted to investigate the therapeutic potential of caffeic acid against amyloid beta (A & beta;(1-42))-induced oxidative stress and memory impairments. A & beta;(1-42) (5 & mu;L/5 min/mouse) was administered intracerebroventricularly (ICV) into wild-type adult mice to induce AD-like pathological changes. Caffeic acid was administered orally at 50 mg/kg/day for two weeks to AD mice. Y-maze and Morris water maze (MWM) behavior tests were conducted to assess memory and cognitive abilities. Western blot and immunofluorescence analyses were used for the biochemical analyses. The behavioral results indicated that caffeic acid administration improved spatial learning, memory, and cognitive abilities in AD mice. Reactive oxygen species (ROS) and lipid peroxidation (LPO) assays were performed and showed that the levels of ROS and LPO were markedly reduced in the caffeic acid-treated mice, as compared to A & beta;-induced AD mice brains. Moreover, the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were regulated with the administration of caffeic acid, compared to the A & beta;-injected mice. Next, we checked the expression of ionized calcium-binding adaptor molecule 1 (Iba-1), glial fibrillary acidic proteins (GFAP), and other inflammatory markers in the experimental mice, which suggested enhanced expression of these markers in AD mice brains, and were reduced with caffeic acid treatment. Furthermore, caffeic acid enhanced synaptic markers in the AD mice model. Additionally, caffeic acid treatment also decreased A & beta; and BACE-1 expression in the A & beta;-induced AD mice model. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Caffeic Acid, a Polyphenolic Micronutrient Rescues Mice Brains against A & beta;-Induced Neurodegeneration and Memory Impairment | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Khan, Amjad | - |
dc.contributor.affiliatedAuthor | Park, Jun Sung | - |
dc.contributor.affiliatedAuthor | Kang, Min Hwa | - |
dc.contributor.affiliatedAuthor | Lee, Hyeon Jin | - |
dc.contributor.affiliatedAuthor | Ali, Jawad | - |
dc.contributor.affiliatedAuthor | Tahir, Muhammad | - |
dc.contributor.affiliatedAuthor | Choe, Kyonghwan | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Ok | - |
dc.identifier.doi | 10.3390/antiox12061284 | - |
dc.identifier.scopusid | 2-s2.0-85163827504 | - |
dc.identifier.wosid | 001013916600001 | - |
dc.identifier.bibliographicCitation | ANTIOXIDANTS, v.12, no.6 | - |
dc.relation.isPartOf | ANTIOXIDANTS | - |
dc.citation.title | ANTIOXIDANTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 6 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | AMYLOID-BETA | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | TAU | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | IGF-1 | - |
dc.subject.keywordPlus | VEGF | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | amyloid beta | - |
dc.subject.keywordAuthor | caffeic acid | - |
dc.subject.keywordAuthor | neurodegeneration | - |
dc.subject.keywordAuthor | antioxidants | - |
dc.subject.keywordAuthor | neuroprotection | - |
dc.subject.keywordAuthor | polyphenols | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Gyeongsang National University Central Library, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea+82-55-772-0533
COPYRIGHT 2022 GYEONGSANG NATIONAL UNIVERSITY LIBRARY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.