상세 보기
- Han, Jeong G.;
- Cho, J.-H.;
- Park, K.-I.;
- Kim, K.;
- Hoon, Kim T.
WEB OF SCIENCE
1SCOPUS
2초록
A rapid and simple enzymatic transformation of the representative coumarin esculetin (1) with polyphenol oxidase originating from Agaricus bisporus afforded five new oxidized metabolites, esculetinins A (2), B (3), C (4), D (5), and E (6), together with the known compound isoeuphorbetin (7). The structures of the oligomerized transformation products were established on the basis of spectroscopic interpretations. The esculetin oligomers 2 and 3 revealed highly enhanced inhibitory activities against α-glucosidase, with IC50 values of 0.7 ± 0.1 and 2.3 ± 0.3 μM, respectively, as compared to the original esculetin. Kinetic analysis also exhibited that the two new potent metabolites 2 and 3 have competitive modes of action. © 2023 Elsevier Ltd
키워드
- 제목
- Enzymatic transformation of esculetin as a potent class of α-glucosidase inhibitors
- 저자
- Han, Jeong G.; Cho, J.-H.; Park, K.-I.; Kim, K.; Hoon, Kim T.
- 발행일
- 2023-05
- 유형
- Article
- 권
- 88