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Novel Hybrid Molecules Based on (-)-Epigallocatechin Gallate as Potent Anti-adipogenic Agentsopen access
- Authors
- Jeong, Gyeong Han; Cho, Jae-Hyeon; Jo, Cheorun; Park, Seungil; Kim, Seong Bong; Kim, Tae Hoon
- Issue Date
- Dec-2020
- Publisher
- Pharmaceutical Society of Japan
- Keywords
- hybrid compound; (-)-epigallocatechin gallate; phloroglucinol; dielectric barrier discharge plasma; adipogenesis
- Citation
- Chemical and Pharmaceutical Bulletin, v.68, no.12, pp 1155 - 1162
- Pages
- 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- Chemical and Pharmaceutical Bulletin
- Volume
- 68
- Number
- 12
- Start Page
- 1155
- End Page
- 1162
- ISSN
- 0009-2363
1347-5223
- Abstract
- A series of novel (-)-epigallocatechin gallate (EGCG)-phloroglucinol hybrid compounds 1-4 has been successfully synthesized by employing a simple and efficient methodology using a dielectric barrier discharge (DBD) plasma irradiation. The new hybrid structures were determined by interpretation of spectroscopic data, with the absolute configurations being established by analysis of the circular dichroism (CD) spectra. The novel hybrids 1 and 2 showed highly improved anti-adipogenic potencies toward both pancreatic lipase and preadipocytes differentiation in 3T3-L1 compared to the original EGCG and phloroglucinol. A novel hybrid 1 represent an interesting subclass of anti-adipogenic candidates that need further research.
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