Critical role of neutralizing antibody for SARS-CoV-2 reinfection and transmissionopen access
- Kim, Young-Il; Kim, Se-Mi; Park, Su-Jin; Kim, Eun-Ha; Yu, Kwang-Min; Chang, Jae-Hyung; Kim, Eun Ji; Casel, Mark Anthony B.; Rollon, Rare; Jang, Seung-Gyu; Um, Jihye; Song, Min-Suk; Jeong, Hye Won; Kim, Eung-Gook; Kim, Yeonjae; Kim, So Yeon; Park, Jun-Sun; Park, Mi Sun; Kwon, Geun-Yong; Yeo, Sang Gu; Lee, Shin-Ae; Choi, Youn Jung; Jung, Jae U.; Choi, Young Ki
- Issue Date
- TAYLOR & FRANCIS LTD
- SARS-CoV-2; reinfection; COVID-19; neutralizing antibody; ferret model
- EMERGING MICROBES & INFECTIONS, v.10, no.1, pp.152 - 160
- Journal Title
- EMERGING MICROBES & INFECTIONS
- Start Page
- End Page
- Cases of laboratory-confirmed SARS-CoV-2 reinfection have been reported in a number of countries. Further, the level of natural immunity induced by SARS-CoV-2 infection is not fully clear, nor is it clear if a primary infection is protective against reinfection. To investigate the potential association between serum antibody titres and reinfection of SARS-CoV-2, ferrets with different levels of NAb titres after primary SARS-CoV-2 infection were subjected to reinfection with a heterologous SARS-CoV-2 strain. All heterologous SARS-CoV-2 reinfected ferrets showed active virus replication in the upper respiratory and gastro-intestinal tracts. However, the high NAb titre group showed attenuated viral replication and rapid viral clearance. In addition, direct-contact transmission was observed only from reinfected ferrets with low NAb titres (<20), and not from other groups. Further, lung histopathology demonstrated the presence of limited inflammatory regions in the high NAb titre groups compared with control and low NAb groups. This study demonstrates a close correlation between a low NAb titre and SARS-CoV-2 reinfection in a recovered ferret reinfection model.
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- 자연과학대학 > Division of Life Sciences > Journal Articles
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