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Structures and Biosynthetic Pathway of Coprisamides C and D, 2-Alkenylcinnamic Acid-Containing Peptides from the Gut Bacterium of the Carrion Beetle Silpha perforata

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dc.contributor.authorShin, Yern-Hyerk-
dc.contributor.authorBan, Yeon Hee-
dc.contributor.authorKim, Tae Ho-
dc.contributor.authorBae, Eun Seo-
dc.contributor.authorShin, Jongheon-
dc.contributor.authorLee, Sang Kook-
dc.contributor.authorJang, Jichan-
dc.contributor.authorYoon, Yeo Joon-
dc.contributor.authorOh, Dong-Chan-
dc.date.accessioned2022-12-26T10:45:26Z-
dc.date.available2022-12-26T10:45:26Z-
dc.date.issued2021-02-26-
dc.identifier.issn0163-3864-
dc.identifier.issn1520-6025-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/4069-
dc.description.abstractCoprisamides C and D (1 and 2) were isolated from a gut bacterium, Micromonospora sp. UTJ3, of the carrion beetle Silpha perforata. Based on the combined analysis of UV, MS, and NMR spectral data, the planar structures of 1 and 2 were elucidated to be unreported derivatives of coprisamides A and B, cyclic depsipeptides bearing a 2-alkenylcinnamic acid unit and the unusual amino acids beta-methylaspartic acid and 2,3-diaminopropanoic acid. The absolute configuration of 1 was determined using the advanced Marfey's method, phenylglycine methyl ester derivatization, and J-based configuration analysis. The biosynthetic gene clusters for the coprisamides were investigated based on genomic data from coprisamide-producing strains Micromonospora sp. UTJ3 and Streptomyces sp. SNU533. Coprisamide C (1) was active against the Mycobacterium tuberculosis mc(2) 6230 strain.-
dc.format.extent8-
dc.language영어-
dc.language.isoENG-
dc.publisherAmerican Chemical Society-
dc.titleStructures and Biosynthetic Pathway of Coprisamides C and D, 2-Alkenylcinnamic Acid-Containing Peptides from the Gut Bacterium of the Carrion Beetle Silpha perforata-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1021/acs.jnatprod.0c00864-
dc.identifier.scopusid2-s2.0-85101436580-
dc.identifier.wosid000624549800007-
dc.identifier.bibliographicCitationJournal of Natural Products, v.84, no.2, pp 239 - 246-
dc.citation.titleJournal of Natural Products-
dc.citation.volume84-
dc.citation.number2-
dc.citation.startPage239-
dc.citation.endPage246-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
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