Detailed Information

Cited 5 time in webofscience Cited 7 time in scopus
Metadata Downloads

The Role of Nuclear Factor of Activated T Cells 5 in Hyperosmotic Stress-Exposed Human Lens Epithelial Cells

Full metadata record
DC Field Value Language
dc.contributor.authorKim, Gyu-Nam-
dc.contributor.authorHah, Young-Sool-
dc.contributor.authorSeong, Hyemin-
dc.contributor.authorYoo, Woong-Sun-
dc.contributor.authorChoi, Mee-Young-
dc.contributor.authorCho, Hee-Young-
dc.contributor.authorYun, Seung Pil-
dc.contributor.authorKim, Seong-Jae-
dc.date.accessioned2022-12-26T10:16:06Z-
dc.date.available2022-12-26T10:16:06Z-
dc.date.issued2021-06-
dc.identifier.issn1661-6596-
dc.identifier.issn1422-0067-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/3632-
dc.description.abstractWe investigated the role of nuclear factor of activated T cells 5 (NFAT5) under hyperosmotic conditions in human lens epithelial cells (HLECs). Hyperosmotic stress decreased the viability of human lens epithelial B-3 cells and significantly increased NFAT5 expression. Hyperosmotic stress-induced cell death occurred to a greater extent in NFAT5-knockout (KO) cells than in NFAT5 wild-type (NFAT5 WT) cells. Bcl-2 and Bcl-xl expression was down-regulated in NFAT5 WT cells and NFAT5 KO cells under hyperosmotic stress. Pre-treatment with a necroptosis inhibitor (necrostatin-1) significantly blocked hyperosmotic stress-induced death of NFAT5 KO cells, but not of NFAT5 WT cells. The phosphorylation levels of receptor-interacting protein kinase 1 (RIP1) and RIP3, which indicate the occurrence of necroptosis, were up-regulated in NFAT5 KO cells, suggesting that death of these cells is predominantly related to the necroptosis pathway. This finding is the first to report that necroptosis occurs when lens epithelial cells are exposed to hyperosmolar conditions, and that NFAT5 is involved in this process.-
dc.language영어-
dc.language.isoENG-
dc.publisherMDPI-
dc.titleThe Role of Nuclear Factor of Activated T Cells 5 in Hyperosmotic Stress-Exposed Human Lens Epithelial Cells-
dc.typeArticle-
dc.publisher.location스위스-
dc.identifier.doi10.3390/ijms22126296-
dc.identifier.scopusid2-s2.0-85107575281-
dc.identifier.wosid000666685700001-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.22, no.12-
dc.citation.titleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.citation.volume22-
dc.citation.number12-
dc.type.docTypeArticle-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusENHANCER-BINDING PROTEIN-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusTRANSCRIPTION-
dc.subject.keywordPlusDEATH-
dc.subject.keywordPlusDEHYDRATION-
dc.subject.keywordPlusCATARACT-
dc.subject.keywordPlusNFAT5-
dc.subject.keywordPlusPHOSPHORYLATION-
dc.subject.keywordPlusPROLIFERATION-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordAuthorhuman lens epithelial cell-
dc.subject.keywordAuthorhyperosmotic stress-
dc.subject.keywordAuthornecroptosis-
dc.subject.keywordAuthorNFAT5-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yun, Seung Pil photo

Yun, Seung Pil
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE