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Cited 47 time in webofscience Cited 48 time in scopus
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Production of Multiple Cell-Laden Microtissue Spheroids with a Biomimetic Hepatic-Lobule-Like Structure

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dc.contributor.authorHong, Gyusik-
dc.contributor.authorKim, Jin-
dc.contributor.authorOh, Hyeongkwon-
dc.contributor.authorYun, Seokhwan-
dc.contributor.authorKim, Chul Min-
dc.contributor.authorJeong, Yun-Mi-
dc.contributor.authorYun, Won-Soo-
dc.contributor.authorShim, Jin-Hyung-
dc.contributor.authorJang, Ilho-
dc.contributor.authorKim, C-Yoon-
dc.contributor.authorJin, Songwan-
dc.date.accessioned2022-12-26T10:01:13Z-
dc.date.available2022-12-26T10:01:13Z-
dc.date.issued2021-09-
dc.identifier.issn0935-9648-
dc.identifier.issn1521-4095-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/3340-
dc.description.abstractThe construction of an in vitro 3D cellular model to mimic the human liver is highly desired for drug discovery and clinical applications, such as patient-specific treatment and cell-based therapy in regenerative medicine. However, current bioprinting strategies are limited in their ability to generate multiple cell-laden microtissues with biomimetic structures. This study presents a method for producing hepatic-lobule-like microtissue spheroids using a bioprinting system incorporating a precursor cartridge and microfluidic emulsification system. The multiple cell-laden microtissue spheroids can be successfully generated at a speed of approximately 45 spheroids min(-1) and with a uniform diameter. Hepatic and endothelial cells are patterned in a microtissue spheroid with the biomimetic structure of a liver lobule. The spheroids allow long-term culture with high cell viability, and the structural integrity is maintained longer than that of non-structured spheroids. Furthermore, structured spheroids show high MRP2, albumin, and CD31 expression levels. In addition, the in vivo study reveals that structured microtissue spheroids are stably engrafted. These results demonstrate that the method provides a valuable 3D structured microtissue spheroid model with lobule-like constructs and liver functions.-
dc.language영어-
dc.language.isoENG-
dc.publisherWILEY-VCH Verlag GmbH & Co. KGaA, Weinheim-
dc.titleProduction of Multiple Cell-Laden Microtissue Spheroids with a Biomimetic Hepatic-Lobule-Like Structure-
dc.typeArticle-
dc.publisher.location독일-
dc.identifier.doi10.1002/adma.202102624-
dc.identifier.scopusid2-s2.0-85110443972-
dc.identifier.wosid000674364600001-
dc.identifier.bibliographicCitationAdvanced Materials, v.33, no.36-
dc.citation.titleAdvanced Materials-
dc.citation.volume33-
dc.citation.number36-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaScience & Technology - Other Topics-
dc.relation.journalResearchAreaMaterials Science-
dc.relation.journalResearchAreaPhysics-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryChemistry, Physical-
dc.relation.journalWebOfScienceCategoryNanoscience & Nanotechnology-
dc.relation.journalWebOfScienceCategoryMaterials Science, Multidisciplinary-
dc.relation.journalWebOfScienceCategoryPhysics, Applied-
dc.relation.journalWebOfScienceCategoryPhysics, Condensed Matter-
dc.subject.keywordPlusCULTURE-
dc.subject.keywordPlusTISSUES-
dc.subject.keywordPlusMODELS-
dc.subject.keywordAuthor3D bioprinting-
dc.subject.keywordAuthorhepatic lobules-
dc.subject.keywordAuthormicrotissues-
dc.subject.keywordAuthorpreset extrusions-
dc.subject.keywordAuthorspheroids-
dc.subject.keywordAuthortissue engineering-
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