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Cited 7 time in webofscience Cited 12 time in scopus
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Association Between Thrombogenicity Indices and Coronary Microvascular Dysfunction in Patients With Acute Myocardial Infarctionopen access

Authors
Kang, Min GyuKoo, Bon-KwonTantry, Udaya S.Kim, KyehwanAhn, Jong-HwaPark, Hyun WoongPark, Jeong RangHwang, Seok-JaeHwang, Jin-YongGurbel, Paul A.Samady, HabibKoh, Jin-SinJeong, Young-Hoon
Issue Date
Sep-2021
Publisher
ELSEVIER SCIENCE INC
Keywords
acute myocardial infarction; cardiovascular event; clot strength; coronary microvascular dysfunction; thrombogenicity
Citation
JACC-BASIC TO TRANSLATIONAL SCIENCE, v.6, no.9-10, pp.749 - 761
Indexed
SCIE
SCOPUS
Journal Title
JACC-BASIC TO TRANSLATIONAL SCIENCE
Volume
6
Number
9-10
Start Page
749
End Page
761
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/3337
DOI
10.1016/j.jacbts.2021.08.007
ISSN
2452-302X
Abstract
The association between thrombogenicity and coronary microvascular dysfunction (CMD) has been poorly explored in patients with acute myocardial infarction (AMI). In our real-world clinical practice (N = 116), thrombogenicity was evaluated with thromboelastography and conventional hemostatic measures, and CMD was defined as index of microcirculatory resistance of >40 U using the invasive physiologic test. High platelet-fibrin clot strength (P-FCS) (>= 68 mm) significantly increased the risk of postprocedural CMD (odds ratio: 4.35; 95% CI: 1.74-10.89). Patients with both CMD and high P-FCS had a higher rate of ischemic events compared to non-CMD subjects with low P-FCS (odds ratio: 5.58; 95% CI: 1.31-23.68). This study showed a close association between heightened thrombogenicity and CMD and their prognostic implications after reperfusion in acute myocardial infarction patients. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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