CT 영상 기반 집속 초음파 시뮬레이션 모델의 불균질 물성과 균질 물성에 따른 모델 분석 결과 비교

Abstract

Purpose: Focused ultrasound is an emerging technology for treating the brain locally in a noninvasive man- ner. In this study, we have investigated the influence of skull properties on simulating transcranial pressure field. Methods: A 3D computational model of transcranial focused ultrasound was constructed using female and male CT data to solve for intracranial pressure. For heterogeneous model, the acoustic properties were calculated from CT Hounsfield units based on a porosity. The homogeneous model assigned constant acoustic properties for the single- layered skull. Results: A computational model was validated against empirical data. The homogeneous models were then compared with the heterogeneous model, resulted in 10.87% and 7.19% differences in peak pressure for female and male models respectively. For the focal volume, homogeneous model demonstrated more than 94% overlap com- pared with the heterogeneous model. Conclusion: Homogeneous model can be constructed using MR images that are commonly used for the segmentation of the skull. We propose the possibility of the homogeneous model for the simulating transcranial pressure field owing to comparable focal volume between homogeneous model and hetero- geneous model.