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Cited 36 time in webofscience Cited 38 time in scopus
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Molecular and functional characterization of a cyclophilin with antifungal activity from Chinese cabbage

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dc.contributor.authorLee, Jung Ro-
dc.contributor.authorPark, Seong-Cheol-
dc.contributor.authorKim, Jin-Young-
dc.contributor.authorLee, Seung Sik-
dc.contributor.authorPark, Yoonkyung-
dc.contributor.authorCheong, Gang-Won-
dc.contributor.authorHahm, Kyung-Soo-
dc.contributor.authorLee, Sang Yeol-
dc.date.accessioned2022-12-27T07:03:20Z-
dc.date.available2022-12-27T07:03:20Z-
dc.date.issued2007-02-16-
dc.identifier.issn0006-291X-
dc.identifier.issn1090-2104-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/28441-
dc.description.abstractAn antifungal protein that inhibits the growth of filamentous fungal pathogens was isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) by affinity chromatography on Affi-gel blue gel and ion exchange chromatography on CM-Sepharose. The N-terminal amino acid sequence of the protein was highly homologous to that of plant cyclophilins and consequently the protein was denoted as C-CyP. To understand the antifungal activity of C-CyP, we isolated a cDNA encoding its gene from a Chinese cabbage leaf cDNA library. The Chinese cabbage genome bears more than one C-CyP gene copy and C-CyP mRNA is highly expressed in all tissues except the seeds. Recombinant C-CyP catalyzed the cis-trans inter-conversion of the Ala-Pro bond of the substrate, which indicates this protein has peptidyl-prolyl cis-trans isomerase activity. It also inhibited the growth of several fungal pathogens. (c) 2006 Elsevier Inc. All rights reserved.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.titleMolecular and functional characterization of a cyclophilin with antifungal activity from Chinese cabbage-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1016/j.bbrc.2006.12.102-
dc.identifier.scopusid2-s2.0-33845999879-
dc.identifier.wosid000243570000025-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.353, no.3, pp 672 - 678-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume353-
dc.citation.number3-
dc.citation.startPage672-
dc.citation.endPage678-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.subject.keywordPlusCIS-TRANS-ISOMERASE-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusENDOPLASMIC-RETICULUM-
dc.subject.keywordPlusSIGNAL-TRANSDUCTION-
dc.subject.keywordPlusPROTEASE INHIBITOR-
dc.subject.keywordPlusBINDING-PROTEIN-
dc.subject.keywordPlusCYCLOSPORIN-A-
dc.subject.keywordPlusPEPTIDES-
dc.subject.keywordPlusCDNA-
dc.subject.keywordPlusIMMUNOPHILINS-
dc.subject.keywordAuthorantifungal activity-
dc.subject.keywordAuthorChinese cabbage-
dc.subject.keywordAuthorcyclophilin-
dc.subject.keywordAuthorpeptidyl-prolyl cis-trans isomerase-
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